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Serious side effects of Chantix Depression or neuropsychiatric disorder Suicidal behavior or thoughts Homicidal thoughts Hypersensitivity allergic reaction or angioedema (swelling of the face or body) Serious skin reactions such as Stevens-Johnson Syndrome (includes blisters and peeling skin) or erythema multiforme Arrhythmia (heart rhythm problem), heart attack, stroke, or angina (chest discomfort) Seizure Photosensitivity (light sensitivity) Vision changes Anemia or thrombocytopenia (low platelet or clotting cell count) Kidney stones or kidney failure Gastrointestinal bleeding Pancreatitis (pancreas inflammation) Hypokalemia (low potassium level) Depression Case reports of depressed mood and even suicidal thoughts and aggressive behavior came to light after the release of Chantix